منابع مشابه
Valproic acid monotherapy in pregnancy and major congenital malformations.
BACKGROUND The use of valproic acid in the first trimester of pregnancy is associated with an increased risk of spina bifida, but data on the risks of other congenital malformations are limited. METHODS We first combined data from eight published cohort studies (1565 pregnancies in which the women were exposed to valproic acid, among which 118 major malformations were observed) and identified...
متن کاملCongenital malformations associated with maternal use of valproic acid.
Two children born with birth defects after intrauterine exposure to valproic acid are reported. The mothers took the drug throughout pregnancy as sole treatment for primary generalized epilepsy. The first baby showed facial dysmorphism, arachnodactyly and triphalangeal thumbs. The second had facial dysmorphism, severe laryngeal hypoplasia, tracheomalacia and an aberrant innominate artery that c...
متن کاملCLASSIFICATION OF CONGENITAL MIDDLE AND EXTERNAL EAR MALFORMATIONS: CT STUDY
The authors used high-resolution computed tomography (HRCT) for studying 52 congenitally malformed ears in 45 children between five and 10 years of age. In six children the malformations were bilateral. The malformations clinically manifested as microtia, atresia of the external auditory canal and conductive deafness. Analyzing anatomical details and pathological changes on HRCT axial sec...
متن کاملVALPROIC ACID- valproic acid solution Par Pharmaceutical ----------
WARNINGS: LIFE THREATENING ADVERSE REACTIONS See full prescribing information for complete boxed warning. Hepato toxicity, including fatalities, usually during first 6 months o f treatment. Children under the age of two years and patients with mitochondrial disorders are at higher risk. Monitor patients c losely, and perform serum liver testing prior to therapy and at frequent intervals thereaf...
متن کاملCongenital Malformations
Some are born monsters, some achieve monstrosity; others have monsters thrust upon them! I put myself in the last category. When I first went to work at Southmead Hospital some twelve years ago I was no more or less interested in monsters and congenital malformations than in a great many other things. I soon found however, that this problem was indeed thrust upon me. Monsters and malformations ...
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ژورنال
عنوان ژورنال: Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
سال: 1988
ISSN: 0317-1671,2057-0155
DOI: 10.1017/s0317167100027578